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KMID : 0604520060320020081
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Journal of the Society of Cosmetic Scientists of Korea
2006 Volume.32 No. 2 p.81 ~ p.88
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Anti-aging Effect of Amino Acid Complex on the Skin
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Kim Ki-Ho
Kim Ki-Soo
Kim Young-Heui
Ko Kang-Il
Park Sun-Hee
Kim Jin-Guk
Choi Hyun-Jin
Ko Soo-Yeon
Kim Yong-Min
Bae Yoon-Joo
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Abstract
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Amino acid complex was made with the composition of amino acids quite similar to that of stratum corneum on the skin. In order to evaluate the efficacy of amino acid complex on the skin as an active cosmetic ingredient, we measured cytotoxicity. TIMP-1 expression, moisturizing effect and the amount of horny substance. In cytotoxicity assay, amino acid complex did not show any cytotoxicity. In moisturizing effect test using corneometer, it showed very good moisturizing effect. In TIMP-1 mRNA assay using RT-PCR, moo acid complex showed the increase of TIMP-1 expression, suggesting that amino acid complex have anti-wrinkle effect. Therefore, amino acid complex may be useful as an active ingredient for anti-aging.
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KEYWORD
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amino acid, moisturizing, TIMP-1, anti-aging, cosmetic active ingredient
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